Performance of the 2007 WHO Algorithm to diagnose Smear-negative Pulmonary Tuberculosis in a HIV prevalent setting

The 2007 WHO algorithm for diagnosis of smear-negative pulmonary tuberculosis (PTB) including Mycobacterium tuberculosis (MTB) culture was evaluated in a HIV prevalent area of Kenya

Culture results of smear-negative PTB suspects, prospective study.

a<p>. In 2 patients LJ was negative and TLA was not performed.</p

Diagnostic algorithm for smear-negative TB suspects (prospective study).

<p>Diagnostic algorithm for smear-negative TB suspects (prospective study).</p

Clinical-radiological algorithm ROC curves.

<p>ROC curve for the clinical-radiological smear-negative diagnostic algorithm without culture in the prospective study (A) and in the retrospective analysis of program data (B).</p

Performance of the 2007 WHO diagnostic algorithm for smear-negative PTB without culture in the prospective study and the retrospective analysis of program data (reference: positive culture).

a<p>. One patient excluded since reason to start TB treatment could not be discerned.</p

Patients' characteristics of the smear-negative PTB suspects included in the prospective study.

a<p>. BMI: body mass index.</p>b<p>. Malnourished: BMI<18.5.</p

Factors associated with overtreatment when the diagnostic algorithm without culture was used (prospective study, N = 303).

<p>Factors associated with overtreatment when the diagnostic algorithm without culture was used (prospective study, N = 303).</p